The pancreas is a gland that is located in the upper abdomen
behind the stomach just in front of the spine. It is divided into three
main parts, consisting of a head, body and tail, which weighs between
60-140 grams, and measures about 15 cm x 4 cm. Like many of the bodies
other organs it is also prone to being infected by cancer; however,
unlike certain other cancers it is extremely difficult to detect.
Causes of Pancreatic Cancer
Although it is impossible to tell exactly what causes pancreatic cancer, there are some important principles that cancer biology shows, together with wide based population-studies that do help doctors understand as to why it may develop. Pancreatic cancer is caused by damage to the DNA mutations, which may be hereditary, acquired as one matures, or caused by an individuals lifestyle.
Each person has duplicate genes, "that is to say two copies." One copy is inherited from the mother, and the other copy from the father. In the case of an inherited disease, this is usually from either the mother or the father, where one mutant copy associated with cancer is inherited, together with one normal copy.
As an individual gets older, the normal cell that was inherited may become damaged somewhere along the way, resulting in two bad gene cell copies existing within the pancreas which in turn may grow into cancer at a later date. However, this does not mean that everyone may get cancer, only that a more likely hood may exist.
The lifestyle of an individual may also have some bearing on who gets pancreatic cancer, with modern-day vices such as smoking, heavy-drinking, and bad eating causing obesity, all play their part. Also chance can play a part, where a mistake is made during the division of a cell, when one of the millions of cells that exist in the human-body divides, but does not copy the gene correctly. The human bodies mechanism is near 100% good, however it is not perfect.
Treatments For Pancreatic Cancer
Chemotherapy - Commonly used to treat pancreatic cancer with the drug Gemcitabine, either on its own, or combined with Fluorouracil, Cisplatin, or the more targeted drug Erlotinib.
Radiation Therapy - Used over a period of 5-6 weeks either on its own, or together with chemotherapy, with the objective of shrinking the tumor.
Surgery - The are various forms of surgery that exist for pancreatic cancer.
1. Whipple Surgery (pancreaticoduodenectomy) is used when the tumor is located near to, or within the head of the pancreas, and consists of the removal of the tumor together with portions of the bile duct and stomach.
2. Distal Pancreatectomy is used when the tumor is located in the tail of the pancreas, and consists of the removal of the tail, body, and the spleen.
3. Central Pancreatectomy, or Total Pancreatectomy are used when either the tumor is multi-focal (in more than one location), or affecting the whole of the pancreas, usually when cystic neoplasms or neuroendocrine tumors exist.
Depending on the cancer staging at diagnosis, a combination of treatments may be offered; however, usually they have more down-side potential to offer a patient than any benefit, and are used really as palliative care which tries to minimize the progression of the cancer and relieve some of the symptoms. This is due to pancreatic cancer usually being diagnosed while in a late stage of is metastasis.
Causes of Pancreatic Cancer
Although it is impossible to tell exactly what causes pancreatic cancer, there are some important principles that cancer biology shows, together with wide based population-studies that do help doctors understand as to why it may develop. Pancreatic cancer is caused by damage to the DNA mutations, which may be hereditary, acquired as one matures, or caused by an individuals lifestyle.
Each person has duplicate genes, "that is to say two copies." One copy is inherited from the mother, and the other copy from the father. In the case of an inherited disease, this is usually from either the mother or the father, where one mutant copy associated with cancer is inherited, together with one normal copy.
As an individual gets older, the normal cell that was inherited may become damaged somewhere along the way, resulting in two bad gene cell copies existing within the pancreas which in turn may grow into cancer at a later date. However, this does not mean that everyone may get cancer, only that a more likely hood may exist.
The lifestyle of an individual may also have some bearing on who gets pancreatic cancer, with modern-day vices such as smoking, heavy-drinking, and bad eating causing obesity, all play their part. Also chance can play a part, where a mistake is made during the division of a cell, when one of the millions of cells that exist in the human-body divides, but does not copy the gene correctly. The human bodies mechanism is near 100% good, however it is not perfect.
Treatments For Pancreatic Cancer
Chemotherapy - Commonly used to treat pancreatic cancer with the drug Gemcitabine, either on its own, or combined with Fluorouracil, Cisplatin, or the more targeted drug Erlotinib.
Radiation Therapy - Used over a period of 5-6 weeks either on its own, or together with chemotherapy, with the objective of shrinking the tumor.
Surgery - The are various forms of surgery that exist for pancreatic cancer.
1. Whipple Surgery (pancreaticoduodenectomy) is used when the tumor is located near to, or within the head of the pancreas, and consists of the removal of the tumor together with portions of the bile duct and stomach.
2. Distal Pancreatectomy is used when the tumor is located in the tail of the pancreas, and consists of the removal of the tail, body, and the spleen.
3. Central Pancreatectomy, or Total Pancreatectomy are used when either the tumor is multi-focal (in more than one location), or affecting the whole of the pancreas, usually when cystic neoplasms or neuroendocrine tumors exist.
Depending on the cancer staging at diagnosis, a combination of treatments may be offered; however, usually they have more down-side potential to offer a patient than any benefit, and are used really as palliative care which tries to minimize the progression of the cancer and relieve some of the symptoms. This is due to pancreatic cancer usually being diagnosed while in a late stage of is metastasis.
